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KMID : 0357920030370060400
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Korean Journal of Pathology
2003 Volume.37 No. 6 p.400 ~ p.406
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Expression of MMP-2, MT1-MMP, and TIMP-2 mRNA in Breast Carcinomas
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Kim Dong-Won
Jin So-Young
Lee Dong-Wha
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Abstract
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Background: The activation of proMMP-2 is induced by membrane type 1-matrix metalloproteinase (MT1-MMP), but inhibited by tissue inhibitors of matrix metalloproteinase type 2 (TIMP-2). This study was carried out to establish the pattem of mRNA expression of MMP-2, MT1-MMP, and TIMP-2 in breast carcinomas.
Methods: Seventy-nine cases of invasive ductal carcinoma, 10 of ductal carcinoma in situ, and 10 of fibrocystic disease as a control were analysed for the expression of MMP-2, MT1-MMP, and TIMP-2 mRNA, using in situ hybridization. Correlations of the results with the clinical stage, tumor size, nodal status, and nuciear grade were analysed.
Resulits: The expression rates of MMP-2, MT1-MMP, and TIMP-2 mRNA in invasive ductal carcinoma were 68%, 73%, and 56%, respectively. They were localized to both stromal and tumor cells, but mainly in th latter. The MMP-2 mRNA expression was significantly correlated with the clincal stage (p＜0.05), while the expression of TIMP-2 mRNA was inversely correlated with clinical stage and tumor size(p＜0.05). Significant positive correlations between MMP-2 and MT1-MMP expressions, along with inverserelationships between MMP-2 and TIMP-2, and between TIMP-2 and MT1-MMP, were also found.
Conclusions: MMP-2 and TIMP-2 mRNA expressions might be useful as one of a range of prognostic prameters in breast carcinoma patients.
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KEYWORD
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Breast Neoplasms, Gelatinase A, Tissue Inhibitor of Metalloproteinase 2, Membrane, type 1 Matrix Metalloproteinase, In Situ Hybridization
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